Gif Central boasts hundreds of funny animated gifs. Only the best of the best make it onto this site, with most of them having an accompanying source. No tumblr-esque one-second-long disappointments. No obscure titles or descriptions.
An animated gif of John C. Reilly saying "It's time to go home to Jesus. Goodbye buddy." before putting a pillow over somebody's head. This is from the movie Talladega Nights: The Ballad of Ricky Bobby, in which Reilly plays Cal Naughton.